58 GLP-1RAs potentially may reduce the risk of AF onset and progression through direct and indirect effects on atrial remodelling, including a reduction in systemic inflammation, improvement of cardiomyocyte metabolism, autonomic nervous system modulation, regulation of intracellular Ca 2+ levels and prevention and possibly reversion of atrial fibrosis
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As interest in taking glucagon-like peptide-1 receptor agonist (GLP-1 agonist) medications, such as Zepbound and Wegovy, for weight loss, research continues to examine potential new side effects of these types of drugs
Yet, numerous challenges and uncertainties remain, underscoring the importance of ongoing scientific investigation and collaboration
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