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Future clinical research should investigate the effects of opioid antagonism on the individual ketamine enantiomers and include measurements of relevant metabolites to confirm that observed effects are due primarily to pharmacodynamic interactions rather than alterations in the metabolism or clearance of ketamine

Zhou R, Wang H, Yang Y, Zhang C, Dong X, Du J, et al

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In the RT structure, the cyano group at the position of the Michael acceptor enables fast reaction kinetics, the four-membered azetidine ring improves quantum yield and photostability 17 , and the two carboxylic acid groups ensure aqueous solubility and reduce probe binding to hydrophobic cellular structures