The Zepbound prescribing information outlines a stepwise pattern: start at 2.5 mg once weekly for 4 weeks, then consider increases in 2.5 mg increments after at least 4 weeks on the current dose, with common maintenance doses at 5 mg, 10 mg, or 15 mg once weekly
Conclusion Health insurers are likely to be or have already been exposed to the rise of GLP-1s, and the exposure is expected to expand with approvals for new indications in the pipeline, as well as a projected increase in take-up rates
A few states (like Florida) mandate a comprehensive physical exam before prescribing obesity medications
GLP-treatment could start to become highly personalized: As Horn put it to me, somebody with obstructive sleep apnea may still want to take Zepbound because that drug has proven effective for both that condition and weight loss at the same time
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