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Daily use of broad-spectrum SPF is essential, as melanin synthesis can outpace lightening agents without sunscreen

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In addition, several stress- and metabolism-related genes such as oxidative stress-induced growth inhibitor 1 ( OSGIN1 ), solute carrier family 7 member 11 ( SLC7A11 ), haem oxygenase 1 ( HMOX1 ) and glucose-6-phosphate dehydrogenase ( G6PD ) were also induced

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