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International Journal of Molecular Sciences, 14 (4), 8638-8683
At 2 weeks of age and 7 to 8 days after the induction of gene KO by Tam, the TamCar IGF-IR / mice show significant growth retardation with a body weight that was 70% of their control littermates, and demonstrate severely disorganized growth plates again, due to reduced cell proliferation and delayed differentiation, indicating comparable IGF-IR actions in growth plate development during embryonic and postnatal development (32)
ZhaoXLuXYuLZhangYLiJLiuYet al
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