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Reductions of this magnitude are rare in addiction medicine and what's remarkable is that the finding came from drugs initially designed for diabetes, later repurposed for obesity and never intended to treat addiction

In addition, some sHSPs, such as HSPB1/HSP27 and HSPB5, can be phosphorylated through kinase pathways, including the p38/MK2 pathway, which may regulate their chaperone activity, cytoskeletal interactions, and involvement in autophagy-related clearance of damaged cellular components (Ungelenk et al., 2016

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a Barplot displaying the effect sizes and associated p -values from generalized linear models (GLMs) predicting individual metabolite levels (log 10 -transformed) based on fecal samples

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