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Ultimately, advancements in these areas will determine whether probiotics and related live biotherapeutics can transition from broadly categorized health-promoting supplements to precisely targeted, mechanism-based interventions that are incorporated into evidence-based guidelines for both prevention and treatment (19, 294)

In particular, histamine is a key modulator of serotonin and dopamine activity, both of which play important roles in mood regulation through the activity of reuptake enzymes DERT and SERT