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However, clinical practitioners often recommend a "start low and go slow" approach, particularly for patients with severe chronic illness who may be highly sensitive to new supplements or prone to detoxification reactions (Herxheimer reactions)
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It is crucial to have a strategy in place to manage these aspects, as they play a vital role in dietary adherence and long-term success in weight management
hence, neither participants nor investigators were blinded to group assignments
At the molecular level, preclinical models have suggested a multimodal mechanism
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