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*Correspondence: Jixin Zhong, [email protected]

Blood glucose monitoring and any necessary adjustments to insulin or sulfonylurea doses should be managed under the supervision of the trial team or treating clinician

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Test Subjects (n = 72): Average age of the subjects was 20-70 years old Diagnosed with type 2 diabetes for at least 3 months prior to enrollment No glucose-lowering medications were allowed within 3 months before the trial started (except for Metformin, in which case the dose had to be unchanged) Body mass index (BMI) of 23-50 kg/m, with bodyweight remaining stable ( 1000mg of Metformin daily or (b) undergone a diet and exercise treatment alone Bodyweight had to be within +/- 5kg for 3 months prior to randomization Dosing Schedule: Patients were randomly assigned to the following groups for 36 weeks in a 2:2:2:1:1:1:1:2 ratio, followed by a safety follow-up period of 4 weeks Group #1 = Placebo Group #2 = 1.5mg Dulaglutide injected subcutaneously once a week Group #3 = 0.5mg Retatrutide injected subcutaneously once a week Group #4 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 4mg Group #5 = 4mg Retatrutide injected subcutaneously once a week Group #6 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 8mg Group #7 = 4mg Retatrutide injected subcutaneously once a week, with dose escalation to 8mg Group #8 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 12mg Retatrutide dose was increased every 4 weeks where applicable (i.e

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