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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint
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2008, PMID 18818478
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The researchers utilized standardized scoring systems to quantify cartilage damage, assessing factors including surface irregularity, structural disorganization, and cellular changes
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