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Avignon A et al

Effect of semaglutide on physical function, body composition, and biomarkers of aging in older adults with overweight and insulin resistance: protocol for an open-labeled randomized controlled trial

The strongest human evidence is short-term endocrine pharmacology: GHRP-2 reliably and rapidly releases growth hormone, synergizes with GHRH, and works well enough as a GH-stimulation test to be an approved diagnostic agent in Japan

Quality and purity can vary significantly between sources, making pharmaceutical-grade sourcing essential for clinical use