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Ethics declarations Competing interests HAC received research funds from Janssen, Eli Lilly, Fresenius Kabi and Pfizer, but nothing related to the current manuscript

To confirm that ingested acetaminophen accumulated in Drosophila tissues, we performed immunofluorescence on whole-mounted treated and untreated Drosophila adults using an anti-acetaminophen antibody, which recognizes native acetaminophen and acetaminophen-adducts in tissues 26,27

difficile colonization also leads to a decrease in the abundance of Lachnospiraceae, Ruminococcaceae, and Bacteroides, and an increase in Enterobacteriaceae, further exacerbating GM dysbiosis and thereby influencing the occurrence and development of HCC [127]

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LDL are taken up by cells via LDL receptor-mediated endocytosis, as described above for IDL uptake