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In the safety outcomes trial (DEVOTE), a total of 1429 (37.4%) of the 3818 TRESIBA-treated patients with type 2 diabetes had an eGFR less than 60 mL/min/1.73 m2, and 108 (2.8%) subjects had an eGFR less than 30 mL/min/1.73 m2
At present, the available evidence suggests that both GLP-1 agonist and SGLT2 inhibitors produce unfavourable outcomes, and should be avoided in pregnancy and during lactation
Several studies show long-lived peopleover the age of 100have high concentrations of adiponectin, and suggest this may contribute to their longevity (Bik 2013
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For instance, women tend to eat less as they approach ovulation, and find it harder to resist cravings during perimenopause, when estrogen and other sex hormones are in flux
