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The relative abundance of bacterial genera possessing high bile salt hydrolase (BSH) activity, such as Akkermansia and Bacteroides, varies significantly among individuals, potentially modifying the hosts secondary bile acid pool prior to treatment initiation ( Obesity and HFD are associated with perturbations in bile acid homeostasis, including increased hepatic bile acid synthesis and altered circulating and intestinal bile acid profiles ( Akkermansia and Bacteroides , which include species with bile salt hydrolase activity and actively participate in bile acid deconjugation ( Microbiota-driven changes in deconjugation and downstream transformation can modify the physicochemical properties of bile acids and their reabsorption in the distal ileum, thereby potentially affecting enterohepatic recycling and the relative availability of specific bile acid species within the intestinal lumen ( Gut barrier integrity and inflammation The functional culmination of these microbial shifts, particularly the enrichment of SCFA-producing taxa and BSH-active bacteria, is the preservation of gut barrier integrity and the reduction of systemic low-grade inflammation
Anyone thinking about this medication needs to discuss the potential risks and benefits with a healthcare professional to ensure its a safe and appropriate choice for them
Because it is a small molecule, it is studied orally/sublingually in the literature
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El-Beshlawy, A., El, Accaoui R., Abd El-Sattar, M., Gamal El-Deen, M
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