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Glucagon-like peptide-1 receptor agonists across the spectrum of heart failure
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This indicates that its not a general access across the bloodbrain barrier we have here with our GLP-1 receptor agonist but rather a specialized uptake, likely around circumventricular organs. She concluded with the following key takeaways: Both GLP-1 and acylated GLP-1 analogs have access to discrete brain regions
This tolerability gap may shrink with the optimized titration schedules being tested in Phase 3, but it represents a real limitation of the current Phase 2 protocol
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