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These large scale randomized trials were designed not only to confirm cardiovascular safety but also to evaluate potential cardioprotective effects
Stacking them is physiologically redundant in part: tesamorelin raises endogenous GH and downstream IGF-1, while IGF-1 LR3 adds direct IGF-1R stimulation on top
The semaglutide component follows the same dose escalation schedule as standard compounded semaglutide: Weeks 1-4: 0.25 mg semaglutide (0.1 mL) Weeks 5-8: 0.5 mg semaglutide (0.2 mL) Weeks 9-12: 1.0 mg semaglutide (0.4 mL) Weeks 13-16: 1.7 mg semaglutide (0.68 mL) Week 17+: 2.4 mg semaglutide (0.96 mL) The niacinamide dose scales proportionally with the injection volume
Therefore, indications and recommended dosages are typically based on anecdotal evidence rather than science
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