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Intravenous glutathione studies report headache, dizziness, and localized injection reactions in fewer than 3% of cases

The ADVISE trial attempted to establish a biomarker-guided allocation algorithm for combination immunotherapy, although it achieved treatment matching within 12 days for 87% of patients, it completely failed to predict outcomes in PD-1 resistant populations, with a treatment response rate of zero, highlighting the challenges posed by the dynamic TME for precise modeling (318)

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