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According to this study, both hyperglycemia and hypoglycemia in patients with type 1 diabetes gives rise to endothelial dysfunction, oxidative stress, and inflammation and GLP-1 can be useful to counterbalance these effects

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reactions that worsen after 24 hours, spread beyond 3cm diameter, or produce heat, pus, or streaking signal infection or hypersensitivity

doi: 10.1021/jf4047122 30 LiX.MengZ.MalikA