They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors

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HUBERMAN: Repair of tissues, recovery from exercise, et cetera, but it's not really aimed at longevity per se
Supplementing with Glutathione Glutathione supplementation has mostly been reserved for clinical use due to its high cost and lack of access
Its oral bioavailability makes it practical for long-duration rodent feeding studies and Phase II clinical trials in conditions such as GH-deficient adults, hip fracture recovery models, and age-related sarcopenia research