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These genes, encompassing both risk-associated genes for sporadic PD (e.g., SNCA , LRRK2 , GBA ) and those associated with familial forms (e.g., PARK2 , PINK1 , PARK7 ), predominantly encode proteins involved in critical cellular functions like oxidative stress response, mitochondrial quality control, and protein degradation pathways

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Meng Y, Wang K, Wang T, Tu Y, Gong S, Zhang Y, Zhang G, Au W, Christiani DC, Xia Z-L (2021) Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

This relationship is reciprocal since thyroid conditions can worsen OxS and increase ROS production, exacerbating oxidative damage

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