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Clinical trial data shows discontinuation rates of 4-7% due to GI side effects for semaglutide, and slightly higher (6-9%) for tirzepatide, likely because higher doses are used
The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )
Gastrointestinal sensations may begin subtly within 4 to 6 hours post-injection for sensitive individuals
These findings suggest that cAMP signaling is the main pathway for GLP-1 secretion in GLUTag cells, with glucose-induced signaling amplifying it
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