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Intramuscular injection directly into the muscle adjacent to the injury site (peri-lesional injection) is preferred by some practitioners for localized tendon or ligament pathology, based on the hypothesis that local tissue concentrations will be higher

A larger individual may require more glutathione to reach the "excess" levels needed to impact melanin production

In a human study published that same year, Khavinson and colleagues observed that elderly human subjects who received epithalamin treatment for two to three years experienced a 1.6-1.8 fold decreased mortality rate compared with a control group