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While some peptides benefit from specific timing relative to meals or sleep cycles, TB-500's therapeutic window remains consistent throughout the day

Trial-Reported Endpoints by Phase Trial Lancet 2021 Phase 2 Duration 26 weeks Population Overweight/obese, no T2D (n=706) Mean Weight Loss 10.8% at 4.5 mg vs 3.0% placebo Trial Lancet 2023 Phase 2 Duration 32 weeks Population T2D + obesity (n=92) Mean Weight Loss 8.1% cagrilintide alone

The placebo group barely changed

Most importantly, neither agent has raised major red flags in terms of serious adverse events in the trials conducted to date

Presented for research literature review only Ate NA et al