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10.1038/nature18646 Nature
In adults, alpha-cell progression to maturity was hindered, the mRNA levels of several beta-cell genes (GLUT2, pancreatic duodenal homeobox-1 (PDX-1), and Maf-A) involved in insulin production and secretion were decreased, and there was an increase in the number and rate of proliferation of islet alpha-, beta- and delta-cells
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