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A Japanese clinical review showed significant electrophysiological improvement in neuropathy patients treated with methylcobalamin (Tokuda et al., 2018)
Copper coordination chemistry, briefly What makes GHK-Cu distinctive is how the tripeptide binds copper(II): the imidazole nitrogen of histidine, the N-terminal amine, and backbone nitrogens form a coordination geometry that holds the metal ion with high affinity
Many peptides discussed in this report (Semax, P21, PE-22-28) are valued precisely because they upregulate BDNF
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