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Malins et al

Deficiency of B vitamins in women of childbearing age, pregnant, and lactating women in Brazil: a systematic review

Topical anti-aging effects are biologically plausible because collagen, glycosaminoglycans, skin elasticity, fibroblasts, and extracellular matrix remodeling are all directly relevant to skin aging [2], [4], [12]

The compounds could potentially be combined, as their mechanisms do not overlap

Cortisol dysregulation also becomes more pronounced as estrogen withdrawal activates the HPA axis, producing the elevated baseline stress-hormone output that drives the "tired but wired" pattern common in midlife women