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The RIPENACTB trial reported that 1,200 mg BID NAC was safe in HIV-positive TB patients, though it did not show a significant impact on sputum conversion rate (73)

[1] [2] Menstrual irregularities are not listed as a recognised adverse reaction in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), though some women have reported changes to their menstrual cycle while taking this medication

Metformin reduced mortality in diabetic patients infected with tuberculosis during tuberculosis treatment, and the improved mortality rate was similar to that of non-diabetic tuberculosis patients (131)

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