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ChaC1 and ChaC2 use the -amine of L-glutamyl residues to cleave the amide bond by transamination, releasing it as a cyclic 5-oxo-l-proline and cysteine glycine dipeptide
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As with cholesterol, family history and genetic make-up can play a part in causing raised levels, as can obesity and lack of exercise
NAD+ also plays a critical role in DNA repair through PARP enzymes
Antibiotics are used before and after an appendectomy to prevent wound infections
So, thats an important factor as well
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