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Semaglutide participants experienced higher rates of gallstones and cholecystitis compared to placebo, but this likely reflects the weight loss itself rather than direct medication toxicity

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Clinical trials reveal that tirzepatide (Mounjaro) leads the pack, achieving 15-20% body weight reduction , outperforming both Wegovy and other GLP-1 weight loss medications

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What are the ethical considerations in prescribing GLP-1 agonists to women of childbearing potential, given the risks to fetal development and the necessity of contraception