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Efficacy, adherence and persistence of various glucagon-like peptide-1 agonists: nationwide real-life data

Among these, triple agonists targeting GLP-1, GIP, and glucagon receptors represent a promising next step

We evaluated heterogeneity for the primary outcomes based on the agreement between CIs and prediction intervals in relation to the null effect and the clinically important effect on the opposite direction to the point estimate [16, 17]

When to Contact Your Provider Contact your healthcare provider immediately if you experience: Diarrhea lasting more than 3 days Daily diarrhea throughout the week (not just after injection) Signs of dehydration (dizziness, dry mouth, dark urine, confusion) Severe abdominal pain or cramping Blood or mucus in stool Fever above 101F (38.3C) Significant weight loss Unable to keep fluids down Quick Tips Diarrhea in the first 1-2 days after injection is normal for some patients Track bowel movements to identify patterns Stay near a bathroom if you experience post-injection diarrhea Use barrier cream if experiencing frequent bowel movements Most patients find diarrhea improves after dose stabilization Never ignore persistent diarrheadehydration is dangerous References Nauck MA, et al

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