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Cheng CK, Luo JY, Lau CW, Cho WC, Ng CF, Ma RCW, Tian XY, Huang Y

According to the Mayo Clinic, current frontline options like tirzepatide (Zepbound/Mounjaro) and semaglutide (Wegovy/Ozempic) remain highly reliable, offering 15% to 22% weight loss with lower rates of gastrointestinal side effects

Current guidance derives from animal research, early human trials, and anecdotal experience from research communities

Simple drink up

Proton pump inhibitors (PPIs) such as omeprazole or pantoprazole may help patients experiencing concurrent reflux symptoms, as delayed gastric emptying can worsen gastroesophageal reflux disease