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Constipation affected 24% of users from a 2.4 mg/week dosage (21)

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384 Anlotinib plus sotorasib downregulates c-Myc/ORC2, induces apoptosis, and reverses resistance in KRAS-G12C NSCLC

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FDA's own scientists recommended against it, citing inadequate physicochemical characterization, immunogenicity risk from aggregation and peptide-related impurities, and insufficient evidence of effectiveness

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