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Among these, CJC-1295 stands out as a synthetic analog of Growth Hormone-Releasing Hormone (GHRH)
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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction
In the Phase 2 trial, the 4 mg group had already lost 12.9% of body weight by week 24, compared to 1.6% for placebo
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