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Additional strategies, such as direct activation of gasdermin D 14,15 or delivery of caspase-1 (ref

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Concentration adjustment proves essential with under-eye products requiring 30-50% lower active concentrations than facial formulations to prevent irritation - while 1-2% GHK-Cu works well on face , 0.5-1% proves safer for eye area maintaining effectiveness while minimizing redness or stinging risks