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Lyophilised powder: freeze at -20 C or below immediately on receipt - stable for years Reconstituted solution: refrigerate at 28 C , use within 30 days , never freeze (ice crystals damage the peptide) Topical serums / creams: cool, dark storage

Patients who are also optimizing hormonal status should be aware that sex hormones interact with MOTS-c signaling

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Also, magnesium sulfate heptahydrate (epsomite, MgSO 4 7H 2 O) can be manufactured by dissolution of magnesium sulfate monohydrate (kieserite, MgSO 4 H 2 O) in water and subsequent crystallization of the heptahydrate

Remarkably, all 12 patients reported significant improvement in symptoms and none reported adverse effects in the short term