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The proton leak across the mitochondrial inner membrane
Most people notice a gradual "brightening" or "softening" of dark areas rather than a total disappearance in a few days
Induction of SLC25A39 protein levels was generalizable as two additional cell lines from distinct tissue origins (K562 and HEK-293T) displayed similar responses to BSO (Fig
These results support a useful selectivity window for NNMT research, but they were obtained with a limited panel of related enzymes and do not rule out every possible off-target interaction
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