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Among them, the most typical is the chemokine Leukotriene B4 (LTB4), the increased expression of which causes recruitment of neutrophils, ATMs, T cells, and B cells, which increase expression of pro-inflammatory cytokines, eventually leading to the development of eWAT inflammation and obesity (132) ( Figure 3 )

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When levels drop, it may lead to fatigue, reduced immunity, and increased oxidative stress