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Disappointment features prominently in longer-term accounts

A key double-blind, placebo-controlled phase II study conducted over 72 weeks recruited 320 individuals with histologically confirmed NASH and liver fibrosis classified as stage F1 to F3

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Beyond weight loss numbers, metabolic improvements often become visible by month six

Adiponectin has demonstrated antidiabetic and insulin sensitizing actions (248), in part by suppressing endogenous glucose production (249) and enhancing peripheral fat uptake (250) by increasing lipoprotein lipase activity and enhancing VLDL catabolism (251)