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Population Pharmacokinetic Modelling Datasets containing plasma concentration and covariate data from each trial were converted to a format compatible with the nonlinear mixed-effects modelling (NONMEM) software (ICON Development Solutions, Ellicott City, MD, USA), version 7.1.2

(A) Metabolic pathways significantly altered in non-PT cells from ABMR samples compared to healthy samples, with corresponding NES and adjusted P-values

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In case of any issue or problem in the thymus gland, the synthetic version of thymosin Beta-4 may replace and fill this gap