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Mechanistic Basis for the Rapid Onset of Cardioprotective Benefit The MACE event curves in SELECT diverged early
10.1128/MCB.00467-19 186 ValenteE
(Reference: Wilding et al., NEJM, 2021) Some people experience nausea, constipation, or bloating
Acknowledgements We thank the team of OpenGWAS and UK Biobank database for making the summary data publicly available, and we would like to acknowledge the principal investigators of the studies who made their data openly accessible for research
GLP-1RAs also exert anti-arrhythmic effects via reducing calcium leak from the sarcoplasmic reticulum in ventricular arrhythmia, which has the potential to decrease phosphorylation of the type 2 ryanodine receptor (RyR2) and alleviate the activity of CaMK-II [77]
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