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11, 12, 13 However, the LH is in fact the most potent self-stimulation center in the brain, and given that hungry/food-restricted rats self-stimulate even more than fed rats, an interaction between the metabolic status and reward may require processing by this brain nucleus, 7, 14 although it is also possible that stimulation of the median forebrain bundle, which connects the VTA to the NAc and runs through the LH, may contribute to the reinforcing effects of the intracranial self-stimulation studies
GLP-1 agonists may lessen alcohol, smoking and possibly drug addictions
Some patients may choose to lower their dose to see if they can maintain their weight at a reduced strength
Contamination, incorrect dosing, and degradation are real possibilities
GLP-1 receptor agonists like semaglutide have a half life of hours to days
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