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IL-33, an alarmin cytokine stored in nuclei, is released upon cell damage and has complex effects (can be pro-inflammatory or tissue-protective)

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In turn, these activated CAFs influence other stromal cells, like adipocytes and mesothelial cells, creating a complex network that remodels the ECM, promoting tumor development (Kalluri, 2016)

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FIGURE 4 PDOs derived from other tumor types have also been used in pharmacological screenings

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It Supports the Immune System Glutathione plays an important role in your immune system by playing a key role in proper function of the T-cell lymphocytes

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