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Less than 5% body weight loss after 16 or more weeks at a therapeutic dose (10mg or above) constitutes a poor response
doi: 10.1016/j.celrep.2015.06.062 204 WangY
Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease Exp Neurol 1996
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The subsequent downstream signaling cascade initiated from substrates of the insulin receptor activates kinases and transcription factors vital in promoting cell metabolism, neuronal growth and differentiation, gene transcription, synaptic plasticity, and neuroprotection [133] (Fig
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