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To keep the effects going, maintenance dosages are frequently needed
doi: 10.1084/jem.20190041 194 PothlichetJNiewoldTBVitourDSolhonneBCrowMKSi-TaharM
In relation to histamine, methylation is required for the HNMT enzyme (which breaks down histamine in the brain) and COMT enzyme (which detoxifies oestrogen in the liver)
Ferreira LF, Campbell KS, Reid MB
A., & Fisher, G
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