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Animal studies show it accelerates healing of Achilles tendon injuries, medial collateral ligament tears, and other connective tissue damage

Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status

This selectivity allows GH stimulation without significant activation of stress-related hormone pathways

Figure 3 3.2 UPF and depression 3.2.1 Background on known mechanisms of depression One of the most widely recognized pathophysiological mechanisms involved in the development of mood disorders, such as depression, is the monoamine hypothesis (51)

This means it contributes to homeostasis (balance) and negates excess GH