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The eyelids look firmer and the fine lines and wrinkles around the eyes seem to vanish
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In addition to activating PKGI, cGMP itself contributes to smooth muscle relaxation through direct inhibition of the plasma membrane localized L-type Ca 2+ channels
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When cAMP activation of CREB is CRTC2/3-dependent and serine-133-independent, it inhibits VSMC mitosis
