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[3] These studies also suggest that DSIP could attenuate the excitatory actions of NMDA receptors, further contributing to its sleep-promoting properties
(-)-Vestitol, Salviolone, and their combination showed no toxicity in the safety evaluation experiment To assess the safety of the natural products, we recorded the general behavior, mortality, and body weight of the mice
Importantly, it achieves these effects without impacting blood sugar levels or insulin sensitivity
Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however
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