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To compensate, cardiomyocytes shift to glycolysis for basic energy needs, although this source is insufficient for normal cardiac activity
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Excess ROS damages mitochondrial membranes, oxidizes nucleic acids, lipids, and proteins, and activates apoptotic cascades via cytochrome c release and caspase activation (Hu et al., 2024)
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In the SUSTAIN-6 trial involving over 3,000 people with type 2 diabetes and established heart disease, semaglutide reduced triglycerides by approximately 20% compared to placebo
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