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Published human studies (Dhillo et al., JCEM, 2005) used IV bolus doses and observed rapid hormonal responses
A normal result is progress, even when it doesnt feel like it
The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
A 2021 review of 16 randomized trials found B12 does not reliably reduce fatigue in people who are not deficient
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