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GI effects are the primary concern, primarily nausea, vomiting, diarrhea, and constipation

How Often Is a B12 Injection Needed

10.1038/s41386-019-0411-y 28 RourkeE.LawF

Reconstitution with bacteriostatic water creates an injectable solution

In response to chemical stress, keratinocytes produce and release inflammatory cytokines, chemokines and other signaling markers that rapidly generate cutaneous inflammation 35